There is growing interest in the pronounced variability in the incidence and severity of chronic respiratory diseases such as asthma. It is now known that acute exacerbations are multi-factorial in origin, with pollution, allergens and viruses all implicated, and effective treatment requiring a similarly complex approach that addresses each of the component causes. In this new volume, leading authorities review what is known of these causative factors and the mechanisms by which they exacerbate the symptoms of pulmonary disease, both singly and in combination with each other. The authors evaluate the individual efficacy of current treatments in the light of this knowledge and present new recommendations for formulating effective therapeutic regimens. Key areas covered include: epidemiology; pathophysiology; in-vitro and in-vivo experimental models of asthma exacerbation; treatment and prevention of asthma exacerbations; and, delivery of care. Addressing a topic of great interest, this is a key work for those working in respiratory medicine, pulmonary medicine and immunology, as well as for physiologists.

The book revises the principal strategies for the characterisation of red wines based on compositional profiles of biogenic amines as a source of information. Special attention is paid to toxicological and organoleptic repercussions associated with the presence of these natural components of wines. This book also aims to characterise the red wine through dielectric parameters. An overview of the basics of the dielectric properties of materials, specifically in foods is also presented. Phenolic compounds in wines, especially in red wines, possess strong antioxidant activity in vitro. Phenolic compounds, obtained in red wine, are natural constituents of grapes and wines. They have the largest effect in decreasing atherosclerosis by both hypolipemic and antioxidant mechanisms. Thus, phenolics show a positive effect on human health and they may cause an increase of antioxidant activity of blood plasma. In this book, the effect of total phenolics [TP], total anthocyanins [TA] on the antioxidant activity [AA] is discussed. Furthermore, the applications of the different analytical methods that have been developed so far for the analysis of natural antioxidants in red wine are discussed, such as high-performance liquid chromotography (HPLC), gas chromatography (GC), and capillary electrophoresis (CE). Also, the agents influencing the phenolic profiles of red wine are overviewed. Wine safety and healthiness depend on the interactions among various factors, several of which of microbial origin. This book explores scientific knowledge on the microbial role in the healthiness and safety enhancement of red wines, by proposing a specific selection of microbial starters. Furthermore, the growth and metabolism of lactic acid bacteria (LAB), which are essential in the quality of many fermented beverages like cider and wine, are discussed. In addition to malic acid, some other organic acids, sugars and carbon sources may be utilised by LAB modifying the sensory quality of these products. In fruit juice and related product, for example, they are considered spoilage microorganisms. Sulphur dioxide (SO2) is one of the most debated chemical components used in enology. Its important antioxidant, preservative and antiseptic properties are indispensable for the health, stability and quality of wine. Flow injection analysis offers great potentials on the field of automation in terms of high sampling rate, precision, accuracy and cost effectiveness. This book reviews automated flow injection methods for the determination of sulphur dioxide in wines. Moderate wine intake could play a protective role in several systems, including cardiovascular, digestive and neuroendocrine ones. Since the description of the French paradox, many beneficial effects of red wine have been described, namely those linked to cardiovascular disease protection. The most recent findings regarding the effects of red wine or its components on the adipose tissue are reviewed. In addition, it has been shown that red wine polyphenolics causes substantial falls in blood pressure, thus improving endothelial function and decreasing oxidative stress. These studies on vascular endothelium are also looked at. The main component considered responsible for the reduced risk of death in alcoholic beverages is ethanol. This book reviews the data generated to date on the amount of phenolic compounds necessary to elicit certain cardioprotective effects. This data may have implications for national alcohol and dietary guidelines, for medical practitioners who 'prescribe' daily moderate wine consumption, as well as for the wine industry per se redeveloping healthier wine styles and types.